Considering that most health issues from a skinned knee, twisted ankle or even normal wear and tear involve some level of pain, it only makes sense to decipher the mechanism behind this feeling and find a means to manage it. For centuries, various remedies provided some pain relief until a breakthrough occurred in the discovery that the hormone-like compounds called prostaglandins, which are the cause of inflammation and thus the producers of pain, could be blocked. By inhibiting an enzyme known as Cyclooxygenase-2 (COX-2), which triggers the release of prostaglandins, there exists a solution to pain management.